Ultrastructural Transformation in Mitochondria Isolated from Kidneys of Normal and Lead-intoxicated Rats

P-98: Ultrastructural Study of Basement Membrane of Seminiferous Tubules in Adult Diabetic Rats with Spermatogenic Alterations

Background: The complications of diabetes are the major problems that occur in diabetic patients. It has been reported that, insulin insufficiency and the impairment of regulatory action of this hormone on Leydig and Sertoli cells have an important role in testicular alterations. Testicular disorders and change in normal spermatogenesis is one of the consequences of diabetes. This study was des...

Inhibitory Effects of Resveratrol against Mitochondrial Toxicity Induced by Perfluorooctanoic Acid in Isolated Liver Mitochondria of Male Rats

 Background and purpose: Resveratrol (RSV) is a naturally polyphenolic compound found in grapes and other plant sources. It has potent free radical scavenger and antioxidative properties.The aim of this study was to evaluate the protective effect of resveratrol against Perfluorooctanoic acid (PFOA) induced mitochondrial toxicity in isolated liver mitochondria. Materials and methods: Mitochondr...

Schizophrenia Induces Oxidative Stress and Cytochrome C Release in Isolated Rat Brain Mitochondria: a Possible Pathway for Induction of Apoptosis and Neurodegeneration

Schizophrenia is a chronic and often debilitating illness which affects about 1% of the world population. Some reagents have been used to simulate schizophrenic disorders in laboratory animals, such as amphetamine and ketamine. Previous studies have suggested that reactive oxygen species (ROS) production, reduced levels of ATP, mitochondrial dysfunction and apoptosis are involved in the pathoph...

Comparison Between Effect of Grape Fermentative Product (red wine) and Fresh Red Grape Juice on Antioxidant Biomarkers of Liver Mitochondria Isolated from Rats in vitro

The Effect of Lactobacillus Fermentum against Lead-Induced Oxidative Damages in Rat Kidneys

Background: Kidneys are the most vulnerable organs with respect to oxidative stress caused by lead poisoning. In this study, renal biomarkers were investigated in rats, exposed to lead after treatment with or without Lactobacillus fermentum. Methods: Twenty-four rats were divided into four groups of five each as follows: a) control, b) lead-exposed, c) Lactobacillus fermentum–treated, and d)...